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P-gp inhibitor 1

CAS No. 2050747-49-2

P-gp inhibitor 1 ( —— )

Catalog No. M26354 CAS No. 2050747-49-2

P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    P-gp inhibitor 1
  • Note
    Research use only, not for human use.
  • Brief Description
    P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).
  • Description
    P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).(In Vitro):In K562/A02 MDR cells, P-gp inhibitor 1 (0.1, 1, 5 μM, 1 h) boosts the potency of other MDR-related cytotoxic agents with different structures, increases the accumulation of DOX, blocks Pgp-mediated Rh123 efflux, and suppresses P-gp ATPase activity.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Histamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2050747-49-2
  • Formula Weight
    517.6
  • Molecular Formula
    C32H31N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1cc2CCN(CCc3ccc(Nc4nc(nc5ccccc45)-c4ccncc4)cc3)Cc2cc1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Miura M, Uno T. Clinical pharmacokinetics of fexofenadine enantiomers. Expert Opin Drug Metab Toxicol. 2010 Jan;6(1):69-74.
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